Biorontech provides integrated gene-to-structure services. We have year-round access to several 3rd generation synchrotron facilities around the world: the Advanced Photon Source (APS), National Synchrotron Light Source II (NSLS II) and the Shanghai Synchrotron Radiation Facility (SSRF) etc. Customers can select some or all services listed below:
Gene synthesis
Codon Optimization and gene synthesis within 2～3 weeks.
Clone or sub-clone
Clone or sub-clone your target gene to Bacterial or Baculovirus vector systems.
Protein expression
Protein expression will be optimized in a E.coli or Baculoviral expression system.
Protein purification
We use various liquid chromatography techniques (AC, IEX, HIC, multi-mode and SEC) and design of experiment (DOE) for optimal protein purification. We also provide services for protein purification process development to pilot scale.
Protein crystallization
- Sparse matrix screen
- Co-crystallization with compound
- Compound soaking
- Optimization with seeding
Synchrotron data collection
We provide high quality, cost-effective synchrotron data collection service at state-of-the-art macromolecular crystallography beamlines located at several 3rd generation synchrotron facilities worldwide (e.g. APS, ALS, NSLS II, Shanghai Synchrotron Radiation Facility SSRF and synchrotron facilities in Europe). We obtain beamtime under proprietary user agreements with respective synchrotron facilities and guarantee your sample confidentiality. Our access to multiple synchrotron facilities allows uninterrupted data collection service throughout the year. We accept mail- in protein crystals for data collection and structure determination.
Structure determination and refinement
Biorontech scientists are highly experienced protein crystallographers. We work closely with customers to meet their structural solution needs in either FTE or project based mode in a most efficient way.
For more information or a price quote, please send an email to service@biorontech.com.